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Staff Scientist, Cell Biology (Hybridoma Specialist)

Job Description
When you?re part of the team at Thermo Fisher Scientific, you?ll do important work, like helping customers in finding cures for cancer, protecting the environment or making sure our food is safe. Your work will have real-world impact, and you?ll be supported in achieving your career goals.
We are seeking a talented and highly motivated candidate for the Staff Scientist position in R&D, Cell Biology experienced in antigen expression and antibody generation. This position offers the opportunity to contribute to the development, production, and improvement of antibody detection products in transplant diagnostics. The candidate is expected to have a broad spectrum of technical working knowledge in mammalian cell culture, membrane protein expression, purification and characterization, flow cytometry, and cell line (including hybridoma) generation with scientific rigor in a regulatory environment. Experiences in assay development characterizing antibody-antigen interactions are highly desired. Skills in instrumentation, automation and software applications are additional assets.
Location/Division Specific Information
Canoga Park, CA / Transplant Diagnostics (TDX)
How will you make an impact?
The Staff Scientist, Cell Biology serves as a technical lead to explore new technologies and identify creative and robust solutions to overcome current technological limitations in Ab detection products for the HLA genes or other relevant target genes. This role will be under the guidance of R&D Sr. Manager and R&D Sr. Director.
What will you do?
+ Evaluate cell line performance based on protein purification and characterization preferably at an earlier stage in the workflow
+ Increase the success rate of hybridoma generation by improving immunogen preparation, fusion efficiency, and screening capacity
+ Devise immunization and hybridoma screening strategy targeting membrane antigen
+ Profile binding specificity, affinity, and kinetics of antibodies from various sources including hybridomas and human sera
+ Curate antibody inventories and identify their potential based on updated info
+ Acquire expertise in One Lambda products, software and instrument
+ Work closely with Cell Biology team on a daily basis and provide training of new or revised protocols
+ Collaborate with broader R&D and Manufacturing departments in advancing One Lambda Ab Detection products
+ Assist the management of lab operations and perform lab duties including instrument maintenance, calibration and qualification, and supporting Cell Biology functions in general
+ Participate in project planning and execution, generating reports, and presenting findings in group and R&D meetings
+ Perform all activities in compliance with GLP, GMP and GDP following regulatory and safety policies
How will you get here?
Education / Experience
+ Ph.D. in Cell Biology, Molecular Biology, Biochemistry, Immunology, Genetics or a related discipline in Biological Sciences AND 2 years of postdoctoral experience, preferably in the development of therapeutics or diagnostics; OR a master degree AND 7 years of experience in biotech or biopharmaceutical industry
Knowledge, Skills, Abilities
+ Hands-on experience in mammalian cell culture, protein purification, and hybridoma generation
+ Assay development characterizing antigen-antibody interaction
+ Proficiency in software and database commonly used in biological sciences
+ Excellent communication, documentation and presentation skills
+ Ability to multitask and manage priorities to meet company goals
+ Strong problem-solving skills, identifying root causes, and proposing alternative approaches and possible solutions
Preferred Qualifications:
+ Experience in membrane protein expression and purification
+ Experience in hybridoma generation specifically targeting membrane protein
+ Experience in applying automation
+ R&D experience within the biotech or biopharmaceutical industry
+ Knowledge in the field of human leukocyte antigen (HLA) and transplantation
+ Demonstrated ability in leading cross-functional teams and projects, as well as coordinating with multiple functional areas
At Thermo Fisher Scientific, each one of our 65,000 extraordinary minds has a unique story to tell. Join us and contribute to our singular mission?enabling our customers to make the world healthier, cleaner and safer.
Apply today! http://jobs.thermofisher.com
_Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status._
If you are an individual with a disability who requires reasonable accommodation to complete any part of our application process, click here at https://jobs.thermofisher.com/page/show/eeo-affirmative-action-statement#accessibility for further assistance.
Thermo Fisher Scientific is an EEO/Affirmative Action Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability or any other legally protected status.

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